Prognostic factor of primary liver cancer treated by hypofractionated three-dimensional conformal radiotherapy.
- Author:
Shi-xiong LIANG
1
;
Guo-liang JIANG
;
Xiao-dong ZHU
;
Xiao-long FU
;
Fu-xiang LI
;
Qi-fang HUANG
;
An-yu WANG
;
Long CHEN
;
Hai-jie LU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Hepatocellular; radiotherapy; Female; Follow-Up Studies; Humans; Imaging, Three-Dimensional; Liver Neoplasms; radiotherapy; Male; Middle Aged; Prognosis; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal; methods; Regression Analysis; Retrospective Studies
- From: Chinese Journal of Oncology 2005;27(10):613-615
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the toxicity and efficacy of primary liver cancer (PLC) treated by hypofractionated three-dimensional conformal radiotherapy (3DCRT) and investigate the prognostic factors.
METHODSBetween April 1999 and August 2003, 128 PLC patients received hypofractionated 3DCRT. According to UICC/AJCC staging system, there were 83 T3 patients, 45 T4, with none of them having lymph node metastasis. The mean value of gross tumor volume (GTV) was (458.92 +/- 429.8) cm(3) (6.2-2097 cm(3)). Thirty-four patients had portal vein tumor thrombosis (PVTT). 108 patients had Child-Pugh Grade A liver cirrhosis and 20 Child-Pugh Grade B liver cirrhosis. All patients received a total dose of (53.6 +/- 6.6) Gy/4-8 Gy per fraction/3 fractions per week. Forty-eight of these patients received 3DCRT combined with transarterial chemoembolization (TACE).
RESULTSSeven patients died within 3 months after the treatment were dismissed from the series. The response rate (CR + PR) was 55% (67/121). The overall 1-, 2-, and 3-year survival rate was 65.0%, 43.3%, and 33.1%, respectively. T stage (P = 0.001), GTV (P = 0.0001), PVTT (P = 0.0001) and Child-Pugh Grade (P = 0.0001) had significant impact on the overall survival. However, only GTV and Child-Pugh Grade were independent significant prognostic factors by Cox-regression analysis, (P = 0.044 and P = 0.015).
CONCLUSIONT stage, GTV, PVTT and Child-Pugh Grade have significant impact on the overall survival in primary liver cancer patients treated by three-dimensional conformal radiotherapy. But only GTV and Child-Pugh Grade are independent prognostic factors.
