Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease.
- Author:
Ji Won LEE
1
;
Kyung Yil LEE
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. leekyungyil@yahoo.com
- Publication Type:Original Article
- Keywords:
Intravenous immunoglobulin;
Kawasaki disease;
Proteins;
Lipids;
HDL-cholesterol
- MeSH:
Child;
Cholesterol;
Humans;
Immunoglobulins*;
Immunoglobulins, Intravenous;
Metabolism;
Mucocutaneous Lymph Node Syndrome*;
Triglycerides
- From:Journal of the Korean Pediatric Society
2003;46(8):817-820
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD). METHODS: Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times: before IVIG treatment and two hours, 24 hours and seven days after IVIG treatment. The samples were frozen at -20 degrees C before biochemical analysis. RESULTS: A significant decrease in albumin concentration was found two hours h and 24 hours after IVIG treatment, but this recovered to the pretreatment level after seven days. Total cholesterol and triglyceride increased slightly after seven day. A significant decrease in HDL-cholesterol and C- reactive protein was seen two hours and 24 hours after IVIG treatment. CONCLUSION: High-dose IVIG affects immediate changes in protein profiles and HDL-cholesterol in KD. Changes in HDL-cholesterol induced by IVIG may be the result of changes in systemic protein metabolism.
