Clinicopathologic study and immunohistochemistry comparison of Pax2, p53 and Ki-67 in low- and high-grade ovarian serous carcinomas.
- Author:
Xu-xia SHEN
1
;
Lin YU
;
Rui BI
;
Wen-tao YANG
Author Information
- Publication Type:Journal Article
- MeSH: CA-125 Antigen; metabolism; Cystadenocarcinoma, Serous; classification; metabolism; mortality; pathology; Disease-Free Survival; Female; Follow-Up Studies; Humans; Immunohistochemistry; Ki-67 Antigen; metabolism; Membrane Proteins; metabolism; Middle Aged; Neoplasm Grading; Neoplasm Staging; Ovarian Neoplasms; classification; metabolism; mortality; pathology; Ovary; pathology; PAX2 Transcription Factor; metabolism; Survival Rate; Tumor Suppressor Protein p53; metabolism
- From: Chinese Journal of Pathology 2011;40(8):511-516
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the two-tier system for the grading of ovarian serous carcinomas, and to analyze Pax2, p53, Ki-67 protein expression and their prognostic values for low- and high-grade ovarian serous carcinomas.
METHODSA total of 38 cases of low-grade and 100 cases of high-grade ovarian serous carcinomas were selected based on the two-tier grading system. Immunohistochemistry was used to detect Pax2, p53 and Ki-67 protein expression in all cases. Correlation of the two-tier system with immunohistochemical results and prognostic parameters were performed.
RESULTS(1) The overall survival, disease-free survival and 5-year survival rates were significantly higher in the low-grade serous carcinoma cases than in the high-grade cases (P < 0.05). (2) Significant differences in protein expressions were found between the low- and high-grade serous carcinomas. The high-grade serous carcinomas had a significantly higher expression level of p53 (55.0% vs 13.2%, P < 0.05) and Ki-67 (42.1% vs 13.7%, P < 0.05), while low-grade carcinomas had a significantly higher expression level of Pax2 (65.8% vs 13.0%, P < 0.05). (3) Pax2 positive cases had a significantly better overall survival and 5-year survival rates than Pax2 negative cases (P < 0.05). The expressions of p53 and Ki-67 were found to have little correlation with overall survival and disease-free survival (P > 0.05).
CONCLUSIONSThe two-tier system for the grading of ovarian serous carcinomas has a good prognostic value. There are significantly differences in expressions of Pax2, p53 and Ki-67 between low- and high-grade ovarian serous carcinomas. Compared with p53 and Ki-67, Pax2 is likely a better prognostic indicator for ovarian serous carcinoma.
