Significance of MUM-1/IRF4 protein expression in follicular lymphoma.
- Author:
Ying-ying HUO
1
;
Yi PAN
;
Bing-xin GUAN
;
Ai-ju FANG
;
Bao-cun SUN
;
Geng-yin ZHOU
;
Kai FU
;
Bin MENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; metabolism; DNA-Binding Proteins; metabolism; Female; Humans; Interferon Regulatory Factors; metabolism; Ki-67 Antigen; metabolism; Lymphoma, Follicular; metabolism; pathology; Male; Middle Aged; Neoplasm Grading; Neprilysin; metabolism; Proto-Oncogene Proteins c-bcl-2; metabolism; Proto-Oncogene Proteins c-bcl-6
- From: Chinese Journal of Pathology 2011;40(8):528-531
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of MUM-1/IRF4 and its significance in follicular lymphoma.
METHODSNinety-eight cases of follicular lymphoma were enrolled into the study. They were graded according to the 2008 WHO criteria. The expression of MUM-1/IRF4 protein and other markers (CD10, bcl-6, bcl-2 and Ki-67) was studied using tissue microarray and immunohistochemistry.
RESULTSAmongst the 98 cases studied, there were 24 grade 1 cases, 30 grade 2 cases, 26 grade 3A cases and 18 were grade 3B cases. The rates of expression of MUM-1/IRF4, CD10, bcl-6, bcl-2 and Ki-67 (≥ 25%) were 39.8% (39/98), 62.2% (61/98), 80.6% (79/98), 87.8% (86/98) and 50.0% (49/98), respectively. MUM-1/IRF4 predominantly expressed in high-grade follicular lymphoma and showed a significantly positive correlation with lymphoma grade (r = 0.628, P = 0.000) and Ki-67 index (r = 0.473, P = 0.000). MUM-1/IRF4 expression had a significantly negative correlation with CD10 expression (r = -0.597, P = 0.000), but no correlation with bcl-6 and bcl-2 expression.
CONCLUSIONSMUM-1/IRF4 expression is significantly higher in high-grade follicular lymphoma, indicating that these cases have a high proliferative activity, more aggressive behavior and poorer prognosis. MUM-1/IRF4, when strongly expressed, is another helpful marker for the diagnosis of high-grade follicular lymphoma.
