Nodular hepatocellular carcinoma: treatment with intraarterial injection of I-131 Lipiodol.
- Author:
Hyung Sik YOO
1
;
Jung Ho SUH
;
Jong Tae LEE
;
Ki Whang KIM
;
Dong Ik KIM
;
Byung Soo KIM
;
Heung Jai CHOI
;
Kyung Sik LEE
Author Information
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords: Liver neoplasms therapy; Iodine and iodine compounds radioactive; Liver neoplasms radionuclide studies; Radionuclides therapeutic
- MeSH: Adult; Aged; Angiography; Carcinoma, Hepatocellular/radionuclide imaging/*therapy; Follow-Up Studies; Humans; Infusions, Intra-Arterial; Iodine Radioisotopes/therapeutic use; Iodized Oil/adverse effects/*therapeutic use; Liver Neoplasms/radionuclide imaging/*therapy; Male; Middle Aged
- From:Journal of Korean Medical Science 1990;5(2):75-83
- CountryRepublic of Korea
- Language:English
- Abstract: Twenty four patients with hepatocellular carcinoma who refused surgery or had unresectable tumor ranging 2.5 to 8.0 cm in size were treated with intrahepatic arterial injection of iodine-131-labeled iodized oil (I-131 Lipodol) in an attempt to achieve internal radiation of tumor. 555-2,220 MBq in 3-8 ml of I-131 Lipiodol was injected into the hepatic artery or proximal to the tumor feeding vessel depending on the tumor size. Tumor size reduction was observed in 88.9% of tumor smaller than 4.0 cm in diameter, 65.5% between 4.1 to 6.0 cm, and 25.0% of larger than 6.1cm, respectively. The tumor size reduction was corresponded to the gradual drop of serum AFP levels, decreased uptake on gallium-67 scintigraphy, and devascularization on follow-up angiography. Tumors having significant A-V shunts revealed further tumor growth. Adverse reactions from the treatment include fever, mild abdominal pain, nausea and elevation of transaminases. These have been mild and well-tolerated by the patients. This method was able to provide long term local control without complications related to thyroid, lung, GI tract and bone marrow.
