Effects of Qilan Tangzhining capsule on glucose and lipid metabolism in rats with diabetes mellitus and hyperlipemia.
- Author:
De-qin ZHANG
1
;
Jian-jun ZHANG
;
Jing-xia WANG
;
Su-min HU
;
Wei LI
;
Li-na OU
;
Shao-hong CHEN
;
Xue-min GAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Astragalus membranaceus; chemistry; Blood Glucose; metabolism; Capsules; Diabetes Mellitus, Experimental; blood; chemically induced; complications; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Gynostemma; chemistry; Hyperlipidemias; blood; complications; Lipids; blood; Male; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2005;30(10):773-777
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Qilan Tangzhining capsule on glucose and lipid metabolism in diabetes mellitus and hyperlipemia.
METHODRats were fed with high sugar and fat food for 2 months, then 2% streptozocin (STZ, 30 mg kg(-1)) was injected intraperitoneally to induce hyperglycemia and hyperlipemia. After the model rats were administrated drugs, the blood glucose, the serum lipids, and the histopathology of the liver and pancreas were observed.
RESULTQilan Tangzhining capsule could decrease the FBG and the serum TC, TG, LDL-C, increase HDL-C, and improve the histopathologic injury of the liver and pancreas.
CONCLUSIONQilan Tangzhining capsule can not only adjust the blood glucose and lipid, but also improve the histopathology injury of the liver and pancreas.
