Effects of Guanyu capsule on the behavior and cerebral cortex monoamine neurotransmitters in depressive model of olfactory bulb damage rats.
- Author:
Jing-xia WANG
1
;
Jian-jun ZHANG
;
Gan-sheng ZHONG
;
De-qin ZHANG
;
Su-min HU
;
Wei LI
;
Li-na OU
;
Xue-min GAO
Author Information
- Publication Type:Journal Article
- MeSH: 3,4-Dihydroxyphenylacetic Acid; metabolism; Animals; Behavior, Animal; drug effects; Biogenic Monoamines; metabolism; Cerebral Cortex; metabolism; Curcuma; chemistry; Depression; etiology; metabolism; Dopamine; metabolism; Drugs, Chinese Herbal; isolation & purification; pharmacology; Dryopteris; chemistry; Male; Olfactory Bulb; pathology; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Serotonin; metabolism
- From: China Journal of Chinese Materia Medica 2005;30(10):782-785
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the behavioral changes and the levels of monoamine neurotransmitters in the anterior cortex in the olfactory bulb damage rats after being treated with Guanyu capsules (GYC).
METHODOpen-field test and step-down passive avoidance test were used to observe the behavior in model rats. HPLC-ECD was used to analyze the influences of GYC on the levels of monoamine neurotransmitters.
RESULTIn the model rats, there was a characteristic hyperactivity in the Open-field and learning deficits in step-down passive avoidance (P < 0.01). The contents of 5-HT reduced, and the rate of DOPAC/DA increased significantly (P < 0.01). GYC 1.2, 0.6 g x kg(-1) could correct behavioral changes increase the contents of 5-HT, and decrease DOPAC/DA level (P < 0.01).
CONCLUSIONGYC can correct behavioral changes in rats model of olfactory bulb damage, and regulating 5-HT and DA metabolism in cortex is one of the antidepressive mechanisms of GYC.
