Influence of Xinqin tablets on guinea-pig nasal hypersensitivity.
- Author:
Rong ZHANG
1
;
Yan YU
;
Jun-rong DU
;
Jian LIU
;
Jie ZHANG
;
Ting WEI
;
Xin LI
;
Jiang LI
;
Rui LONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Asarum; chemistry; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Guinea Pigs; Histamine; metabolism; Male; Nasal Mucosa; drug effects; metabolism; pathology; Nitric Oxide Synthase; metabolism; Phytotherapy; Plants, Medicinal; chemistry; Rhinitis, Allergic, Perennial; chemically induced; metabolism; pathology; Scutellaria; chemistry; Toluene 2,4-Diisocyanate
- From: China Journal of Chinese Materia Medica 2005;30(10):785-788
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of Xinqin tablets on guinea-pig nasal hypersensitivity.
METHOD2,4-Toluene Diisocyanate (TDI) was selected as antigen and used in nose to establish guinea-pig allergic rhinitis. The effects of Xinqin tablets on symptoms of nasal hypersensitivity in guinea-pigs, histamine content of nasal mucosa and activity of nitric oxide synthase (NOS) were examined.
RESULTXinqin tablets could significantly relieve the pathological symptoms of nasal hypersensitivity in guinea-pig, reduce histamine content of nasal mucosa and inhibit the activity of nitric oxide synthase.
CONCLUSIONXinqin tablets have significant effect on nasal hypersensitivity, and prevent the occurrence of allergic rhinitis.
