Study on chemical constituents in rhizome of Pinellia ternata.
- Author:
Ping HE
1
;
Shuai LI
;
Su-juan WANG
;
Yong-chun YANG
;
Jian-gong SHI
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents, Phytogenic; chemistry; isolation & purification; pharmacology; Cell Line, Tumor; Cell Proliferation; drug effects; Ergosterol; analogs & derivatives; chemistry; isolation & purification; pharmacology; Humans; Phytosterols; chemistry; isolation & purification; Pinellia; chemistry; Plants, Medicinal; chemistry; Rhizome; chemistry; Stigmasterol; analogs & derivatives; chemistry; isolation & purification; Triterpenes
- From: China Journal of Chinese Materia Medica 2005;30(9):671-674
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents in rhizome of Pinellia ternata.
METHODThe constituents were isolated by silica-gel and Sephadex LH-20 chromatography. The structures were identified by spectroscopic analysis including 2D NMR techniques.
RESULTSix compounds were obtained and identified as stigmast-4-en-3-one(I), cycloartenol(II), 5alpha,8alpha-epidioxyergosta-6,22-dien-3-ol(III), beta-sitosterol-3-O-beta-D-glucoside-6'-eicosanate(IV), alpha-monpalmitin(V), beta-sitosterol(VI). The bioactive assay indicated that: compound III was active against the human tumor cell lines HCT-8, Bel-7402, BGC-823, A549, A2780.
CONCLUSIONCompounds I-IV were isolated from Pinellia ternata for the first time, compound II was the first triterpene isolated from this genus. Compound III may be one of the antitumor constituents of P. ternata.
