Effect of geniposide on serum IL-1beta and TNF-alpha of rheumatoid arthritis rats.
- Author:
Jiang ZHU
1
;
Xin GAO
;
Wen-li XIE
;
Yu-zhang JIN
;
Wen-jun SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arthritis, Rheumatoid; blood; chemically induced; pathology; Collagen Type II; Dose-Response Relationship, Drug; Edema; chemically induced; pathology; Gardenia; chemistry; Hindlimb; pathology; Interleukin-1; blood; Iridoids; administration & dosage; isolation & purification; pharmacology; Male; Plants, Medicinal; chemistry; Pyrans; administration & dosage; isolation & purification; pharmacology; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2005;30(9):708-711
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of geniposide on serum IL-1beta and TNF-alpha levels of rheumatoid arthritis rats, as well as the mechanism of this drug.
METHODTo establish an experimental rat model of type II collagen-induced arthritic (CIA). The inhibitory effects on paw edema were observed, and serum IL-1beta and TNF-alpha levels were determined in experimental rats.
RESULTCompared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1beta and TNF-alpha were significantly decreased by geniposide at high dose or medium dose (P < 0.01).
CONCLUSIONGeniposide can lower serum IL-1beta and TNF-alpha levels in rheumatoid arthritis rats. The effect may be close related to inhibitory development of rheumatoid arthritis by the agent.
