Protective effects of San Baoxin on injury induced by myocardical ischemic reperfusion and anti-thrombosis in rats.
- Author:
Hui-Li GAO
1
;
Yu-Ying WANG
;
Yi-Kui LI
;
Ke-Yong NING
;
Lian-Da LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Fibrinolytic Agents; pharmacology; Male; Malondialdehyde; blood; Myocardial Ischemia; blood; pathology; Myocardial Reperfusion Injury; blood; pathology; Nitric Acid; blood; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Superoxide Dismutase; blood; Thrombosis; pathology
- From: China Journal of Chinese Materia Medica 2005;30(11):844-846
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of San Baoxin on myocardial injury induced by ischemia-reperfusion (MI/R) and thrombogenesis in rats in vivo and ex vivo.
METHODThe experimental model was established by ligation of left anterior descending coronary artery for 30 min followed by reperfusion for 180 min. The Chandler method was used to produced ex vivo thrombosis and an electrical stimulation of common carotid artery was adopted to form in vivo thrombosis respectively, the effect of antithrombosis induced by San Baoxin was observed.
RESULTSan Baoxin significantly decreased the content of malondialdehyde (MDA), obviously elevated the activity of superoxide dismutase (SOD) and increased the amount of NO of the serum simultaneously. The San Baoxin at the dosage of 10 g x kg(-1) could remarkably lengthen the OT ( P < 0.05). All San Baoxin dosages could inhibit the formation of ex vivo thrombosis.
CONCLUSIONSan Baoxin protects the myocardium from injury of ischemic and reperfusion. The protective effect of San Baoxin may be due to that it can dilate vessels, increase the activity of clearance enzyme of free radical and inhibit lipid peroxidation and the formation of ex vivo and in vivo thrombosis.
