Protective effect of purariae isoflavone on apoptosis cells of nasal mocosas in ovariectomized rats.
- Author:
Ben-Ming QI
1
;
Chun-Chun CAI
;
Xiao-Ming DENG
;
Lin ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; Epithelial Cells; pathology; Estradiol Congeners; pharmacology; Female; Isoflavones; isolation & purification; pharmacology; Nasal Mucosa; pathology; Ovariectomy; Plants, Medicinal; chemistry; Protective Agents; isolation & purification; pharmacology; Pueraria; chemistry; Quinestrol; analogs & derivatives; pharmacology; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2005;30(11):855-857
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effect of purariae isoflavone on apoptosis cells of atrophic nasal mucosas in ovariectomized rats.
METHOD60 rats were divided into four groups as control, ovariectomized, ovariectomized + nylestriol (O + N) and ovariectomized + purariae isoflavone (O + P), each with 15 rats. Earlier apotosis cells of mucosas taken from nasal septum were measured with flow cytometry.
RESULTCompared with control group, and the number of apoptosis cells of mucosas increased after being ovariectomized,and the number of apoptosis cells of mucosas in O + N and O + D group didn't change.
CONCLUSIONNylestriol and purariae isoflavone might have effects on protecting cells of mucosas from lacking of estrogen by decreasing apoptosis cells in ovariectomized rats.
