Preparation of transfersomes of vincristine sulfate and study on its prcutaneous penetration.
- Author:
Yi LU
1
;
Shi-Xiang HOU
;
Tong CHEN
;
Yi-Yi SUN
;
Ben-Xia YANG
;
Zi-Yan YUAN
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Animals; Antineoplastic Agents, Phytogenic; administration & dosage; pharmacokinetics; Deoxycholic Acid; Drug Carriers; Hydrogen-Ion Concentration; Mice; Particle Size; Phosphatidylcholines; Skin Absorption; Technology, Pharmaceutical; methods; Vincristine; administration & dosage; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2005;30(12):900-903
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo select the best preparation method of vincristine transfersomes (VCR-T) and predict its possibility of being a new formulation of VCR.
METHODOrthogonal design was used to optimize the preparation methods on the basis of single factor pretests; and the permeation tests in vitro were performed in modified Franz diffusion cells.
RESULTThe optimum formula was: pH was equal to 7.3, the ratio of lecithin to sodium deoxycholate is 70/20, the weight of VCR is 10 mg, hydrating time is 30 minutes. The optimized solution was light yellow and transparent colloid solution. The VCR-T are spherical and smooth with average diameters of 94 nm and an encapsulation ratio of 90%. The test in vitro showed that VCR-T could permeat through mouse skin at zero rate with the cumulative penetrating quality amounting to 63.8%.
CONCLUSIONTransfersomes may become a promising carrier of VCR for clinic use.
