Study on the active protein fractions from scorpii tegument.
- Author:
Li WU
1
;
Li ZHANG
;
Guan-Hua DU
;
Yang LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; B-Lymphocytes; drug effects; Female; Keratins; isolation & purification; pharmacology; Killer Cells, Natural; drug effects; Lymphocyte Activation; drug effects; Mice; Mice, Inbred BALB C; Proteins; isolation & purification; pharmacology; Scorpions; chemistry; Skin; chemistry; T-Lymphocytes; drug effects
- From: China Journal of Chinese Materia Medica 2005;30(14):1083-1086
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEExtracting the total protein from scorpii tegument, investigating its effect on immune system by transformation of T/B cell.
METHODWater-soluble protein(ST1) was extracted by distilled water method and salting-out method, while keratin(ST2) by deoxidization method. Sephadex G-50 was used to isolate the protein. The effects of components isolated by sephadex G-50 on T/B and NK cell were investigated.
RESULTThe protein from scorpii tegument could increase the transformation of T/B cell distinctly in vitro, while no apparent effect on NK cell.
CONCLUSIONProtein from scorpii tegument could modulate the immune system, which may offer a new way for people to find protein drugs.
