Effect of Zinc Doped Calcium Phosphate Coating on Bone Formation and the Underlying Biological Mechanism.
- Author:
Wenjing LUO
;
Jinghui ZHAO
;
Xing MENG
;
Shanshan MA
;
Qianyue SUN
;
Tianqi GUO
;
Yufeng WANG
;
Yanmin ZHOU
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
Calcium;
Calcium Phosphates;
chemistry;
Cell Differentiation;
Cell Proliferation;
Humans;
Ions;
Metal Nanoparticles;
chemistry;
Osteoblasts;
cytology;
Osteogenesis;
Phosphates;
chemistry;
Zinc;
chemistry
- From:
Journal of Biomedical Engineering
2015;32(6):1359-1363
- CountryChina
- Language:Chinese
-
Abstract:
Implant surface modified coating can improve its osteoinductivity, about which simple calcium phosphate coating has been extensively studied. But it has slow osteointegration speed and poor antibacterial property, while other metal ions added, such as nano zinc ion, can compensate for these deficiencies. This paper describes the incorporation form, the effect on physical and chemical properties of the material and the antibacterial property of nano zinc, and summarizes the material's biological property given by calcium ion, zinc ion and inorganic phosphate (Pi), mainly focusing on the influence of these three inorganic ions on osteoblast proliferation, differentiation, protein synthesis and matrix mineralization in order to present the positive function of zinc doped calcium phosphate in the field of bone formation.
