Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder.
- Author:
Yao LU
1
;
Hong-Wei MA
;
Chun-Yan XI
;
Ying ZHANG
;
Yan WANG
;
Lu YAO
;
Jian GAO
;
Wei WANG
;
Mo ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Child; Chronic Disease; Female; Gene Frequency; Genotype; Haplotypes; Humans; Male; Polymorphism, Genetic; Promoter Regions, Genetic; Receptors, Dopamine D4; genetics; Tic Disorders; genetics
- From: Chinese Journal of Contemporary Pediatrics 2006;8(5):357-360
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study a possible association between the three functional polymorphisms in the promoter region of dopamine D4 receptor (DRD4) gene and chronic tic disorder.
METHODSGenomic DNA was isolated from the venous blood leukocytes of 84 unrelated patients with chronic tic disorder (Study group) and 100 healthy unrelated individuals (Control group). Polymorphisms of DRD4, 1240L/S, 616C/G and 521C/T, were genotyped by the allele-specific primer (ASP) PCR. Genotype, allele and haplotype frequencies were analysed by SHEsis online.
RESULTSThere were significant differences in both allele and genotype frequencies (chi(2) = 8.419, P < 0.01; chi(2) = 7.860, P < 0.05 respectively) of DRD4-616C/G between the Study and the Control groups. Haplotypic frequencies of LCT (1240L/S, 616C/G, 521C/T) in the Study group were noticeably higher than in the Control group (chi(2) = 6.371, P < 0.05).
CONCLUSIONSThere is an association between the DRD4-616C/G polymorphism and chronic tic disorder. The individuals with haplotype LCT (1240L/S, 616C/G, 521C/T) are susceptible to this disorder.
