Serologic examination for childhood herpes simplex virus infection.
- Author:
Jian-Ping TANG
1
;
Yu-Jia YANG
;
Dan ZHANG
;
Li-Ping LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Antibodies, Viral; blood; Child; Child, Preschool; Female; Herpes Simplex; diagnosis; immunology; Humans; Immunoglobulin G; blood; Immunoglobulin M; blood; Infant; Infant, Newborn; Male; Retrospective Studies; Serologic Tests; Simplexvirus; immunology
- From: Chinese Journal of Contemporary Pediatrics 2006;8(6):476-478
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study was designed to investigate the value of serologic examination in the diagnosis of childhood herpes simplex virus (HSV) infection.
METHODSSerum samples were collected from 2 436 outpatients and inpatients. The samples were divided into two groups. Group 1 consisted of 321 samples which were assayed for HSV-1 IgG, HSV-1 IgM, HSV-2 IgG or HSV-2 IgM antibody using herpes simplex virus antibody kits between January 2003 and November 2005. Group 2 consisted of 2115 samples which were assayed for HSV-2 IgG and IgM antibodies by TORCH testing between October 2004 and November 2005.
RESULTSIn Group 1, the total seroprevalence of HSV infection was 44.6%, with 38.9% being HSV-1 positive and 15.9% HSV-2 positive; HSV-IgM positivity was found in 41.1% and 25.5% were HSV-IgG positive; HSV-1 seroprevalence significantly increased with age (P < 0.05). In Group 2 the seroprevalence of HSV-2 infection was 1.9%; all of the samples were HSV-2 IgG positive.
CONCLUSIONSHSV serologic examination is useful in the diagnosis of HSV infection in children.
