A Case of Lupus Erythematosus Panniculitis with Infiltration of Atypical Lymphocytes.
- Author:
Sung Ju PARK
;
Kwang Soo HAN
;
Ho Gyun LEE
;
Jong Min KIM
- Publication Type:Case Report
- Keywords:
Lupus erythematosus panniculitis;
Atypical lymphocytes
- MeSH:
Adult;
Arm;
Axilla;
Cicatrix;
Female;
Follow-Up Studies;
Gene Rearrangement;
Humans;
Hydroxychloroquine;
Immunoglobulin Heavy Chains;
Lupus Erythematosus, Discoid;
Lymphocytes*;
Nifedipine;
Panniculitis;
Panniculitis, Lupus Erythematosus*;
Prednisolone;
Raynaud Disease;
Receptors, Antigen, T-Cell;
Recurrence;
Skin
- From:Korean Journal of Dermatology
1998;36(6):1074-1077
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lupus erythematosus panniculitis is a rare variant of lupus erythematosus primarily involving a panniculus with or without discoid lupus erythematosus in the overlying skin. A 34-year-old woman showed multiple, variable-sized, indurated subcutaneous nodules on both her upper arms and axillae. A Histopathological examination revealed lobular panniculitis with infiltration of several hyperchromatic atypical large lymphocytes. The infiltrated cells were positively stained with LCA, UCHL-1, CD4, CD8, but not with CD20 and CD68. A T cell receptor -chain gene and immunoglobulin heavy chain gene rearrangement study showed no monoclonality. The result of an ANA test was positive at 1: 40 in a homogeneous pattern. Skin lesions were improved by combined therapy with daily hydroxychloroquine 400mg and prednisolone 10mg in a week and after 6weeks, resolved with atrophic depressed scars. After 4 months, she complained of symptoms of the Raynaud phenomenon and was managed by nifedipine. There has been no recurrence during follow-up for 7 months.
