Preparation of fast responsive, pH sensitive polyacrylic acid gel with different pore-forming agents.
- Author:
Yan ZHANG
1
;
Tianwei TAN
Author Information
1. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
- Publication Type:Journal Article
- MeSH:
Acrylic Resins;
chemistry;
Carbonates;
chemistry;
Chitosan;
chemistry;
Hydrogels;
chemical synthesis;
chemistry;
Hydrogen-Ion Concentration;
Ophthalmic Solutions;
chemical synthesis;
chemistry;
Polyethylene Glycols;
chemistry;
Polymers;
Porosity
- From:
Journal of Biomedical Engineering
2007;24(2):363-367
- CountryChina
- Language:Chinese
-
Abstract:
Five kinds of pore-forming agents, including PEG-400, chitosan, the polymer of chitosan and glutin, CaCO3 and NazCO3, were used in this experiment to prepare fast responsive and pH sensitive Polyacrylic acid (PAAc) gel which could be used as the material of punctum plug. The mechanism and effects of pore-forming agents on PAAc gel were studied; besides, the experiment also assessed the effects of the three most effective pore-forming agents on gel's water retention and swelling rate. The results showed that the most suitable dose levels of PEG-400, the polymer and Na2CO3 were 1 ml, 0.8 ml and 1 ml respectively, and PEG-400 was most effective with the same dosage; the gel with PEG-400 as pore-forming agent could finish more than 95% of the swelling process in just 5 minutes, it is suitable for use as punctum plug material.
