Synthesis and properties of poly(hydroxyethyl methacrylate) hydrogel for IOL materials.
- Author:
Fang LIU
1
;
Xiaolian ZHOU
;
Fengping CUI
;
Demin JIA
Author Information
1. College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. mcfliu@scut.edu.cn
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
chemistry;
Humans;
Hydrogel, Polyethylene Glycol Dimethacrylate;
chemistry;
Lenses, Intraocular;
Polyhydroxyethyl Methacrylate;
chemical synthesis;
chemistry;
Tensile Strength
- From:
Journal of Biomedical Engineering
2007;24(3):595-598
- CountryChina
- Language:Chinese
-
Abstract:
Poly (hydroxyethyl methacrylate) (PHEMA) hydrogel for intraocular lens (IOL) materials was synthesized by solution polymerization using 2-hydroxyethyl methacrylate (HEMA) as raw material, ammonium persulfate and sodium pyrosulfite (KPS/SMBS) as catalyst, and trietyleneglycole dimethacrylate (TEGDMA) as cross-linking additive. Effects of reaction time, temperature, dosage of catalyst and cross-linking additive on mechanical strength and the equilibrium water content (EWC) of the PHEMA hydrogel were systematically investigated and their structure and optical property were also characterized. The experimental results showed that the optimum conditions for preparing PHEMA hydrogel are: catalyst 0.5 wt%, cross-linking additive 1.0 wt%, reaction temperature 40 degrees C, reaction time 36 h. Under the optimum conditions, the tensile strength of PHEMA hydrogel prepared is as high as 0.57 MPa, hardness of Shore A is 23.0, EWC is over 40%, and light transmittance is over 97%.
