Pilot study of a cell membrane like biomimetic drug-eluting coronary stent.
- Author:
Dezeng FAN
1
;
Zhiyuan JIA
;
Xinhao YAN
;
Xiaolei LIU
;
Wei DONG
;
Fuyu SUN
;
Jian JI
;
Jianping XU
;
Kefeng REN
;
Weidong CHEN
;
Jiacong SHEN
;
Hong QIU
;
Runlin GAO
Author Information
1. Advanced Technology & Materials Co., Ltd, Beijing 100081, China. fandezeng@aqtmcn.com
- Publication Type:Journal Article
- MeSH:
Angioplasty, Balloon, Coronary;
instrumentation;
Animals;
Coated Materials, Biocompatible;
Coronary Restenosis;
prevention & control;
Drug-Eluting Stents;
Female;
Humans;
Male;
Materials Testing;
Methacrylates;
chemistry;
Phosphorylcholine;
analogs & derivatives;
chemistry;
Pilot Projects;
Polymers;
chemistry;
Prosthesis Design;
Random Allocation;
Sirolimus;
chemistry;
Swine;
Swine, Miniature
- From:
Journal of Biomedical Engineering
2007;24(3):599-602
- CountryChina
- Language:Chinese
-
Abstract:
A novel bioinspired phospholipid copolymer has been synthesized by the radical polymerization of poly2-Methacryloyloxyethylphosphorylcholine (MPC), stearyl methacrylate (SMA), hydroxypropyl methacrylate (HPMA) and trimethoxysilylpropyl methacrylate (TSMA). Contact angle results indicated that the coating surface rearranged to get a more hydrophilic surface at the polymer/water interface. The membrane mimic phosphorylcholine coating surface could resist the platelet adhesion and prolong plasma recalcification time significantly. Rapamycin was used as model drugs to prepare drug-eluting coating. The animal experiments showed that this novel drug-eluting stent could effectively prevent the phenomena of restenosis.
