Relationship between lipid peroxidation in blood and neurobehavioral function changes in coke oven workers.
- Author:
Fang WANG
1
;
Hong-Mei ZHANG
;
Ji-Sheng NIE
;
Cui-E XUE
;
Ying-Tao SHI
;
Qiao NIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Affect; Anxiety; Case-Control Studies; Coke; Fatigue; Glutathione; blood; Humans; Lipid Peroxidation; Male; Malondialdehyde; blood; Middle Aged; Occupational Exposure; adverse effects; Superoxide Dismutase; blood; Young Adult
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(1):15-17
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the coincidence of lipid peroxidation and neurobehavioral function changes in coke oven workers.
METHODSOne hundred and thirty-four coke oven workers were divided into three groups: 35 in the oven-bottom group, 49 in the oven-side group and 50 in oven-top group. WHO recommended NCTB was performed on coke oven workers and 36 controls from material conservation department; The contents of total superoxide dismutases (T-SOD), glutathione (GSH) and malondialdehyde (MDA) in blood were determined by test kits.
RESULTSCompared with the controls, the coke oven workers showed lower levels of T-SOD and GSH (P < 0.01), significantly higher MDA levels in blood (P < 0.01), higher score on negative mood state, lower scores on positive mood state, and poorer performance in NCTB test (P < 0.05). Further analysis revealed that there was a weak positive correlation between neurobehavioral function changes and the level of lipid peroxidation with a coefficient lower than 0.25.
CONCLUSIONThe level of lipid peroxidation in coke oven workers' blood increased and coincided with neurobehavioral function impairment.