Association between genetic polymorphisms of DNA repair genes XRCC1, XRCC3 and susceptibility to chronic benzene poisoning.
- Author:
Hui-long HUANG
1
;
Jian-ning XU
;
Quan-kai WANG
;
Min YANG
;
Ya-wen WANG
;
Yan CHEN
;
Gui-lan LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Benzene; poisoning; Case-Control Studies; Chronic Disease; DNA-Binding Proteins; genetics; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Occupational Diseases; genetics; Polymorphism, Genetic; X-ray Repair Cross Complementing Protein 1
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(4):193-196
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association between genetic polymorphisms of DNA repair genes XRCC1, XRCC3 and susceptibility to chronic benzene poisoning.
METHODSA case-control study was conducted. Eighty patients with chronic benzene poisoning and 62 workers occupationally exposed to benzene who were engaged in the same working time and job title as patients were investigated. Polymerase chain reaction-restriction fragments length polymorphism (PCR-RFLP) was used to detect the single nucleotide polymorphisms on C26304T, G27466A, G28152A, G36189A of XRCC1 and C18067T of XRCC3. The relationship between them and latency of chronic benzene poisoning was analyzed by Kaplan-Meier method.
RESULTSA correlation for XRCC3 18067C/T compared with C/C genotype was found (OR=0.233, 95% CI 0.085 approximately 0.639, P=0.0046). Patients who were XRCC1 27466G/G homozygous wild genotype developed chronic benzene poisoning average 6 years later than those had homozygous (27466A/A) or heterozygous (27466G/A) mutant alleles.
CONCLUSIONSubjects with XRCC3 18067T variant allele are tolerance sub-group to benzene poisoning. Patients carrying XRCC1 27466 G/G genotype develop chronic benzene poisoning later.
