Changes in T lymphocyte subsets and plasma Th1/Th2 cytokine levels in patients with occupational chronic lead poisoning.
- Author:
Jia-yu CHEN
1
;
Wei YU
;
Wei-wei LIU
;
Ying LUO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chronic Disease; Cytokines; blood; Female; Humans; Lead Poisoning; blood; immunology; Male; T-Lymphocyte Subsets; immunology; Young Adult
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(5):279-281
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes in T lymphocyte subsets and plasma Th1/Th2 cytokine levels in patients with occupational chronic lead poisoning.
METHODSFlow cytometric analysis was used to count the numbers of CD3+, CD4+, CD8+ cells and cytometric bead array CBA capture technique was used to quantify plasma IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma concentrations. Twenty-three patients with occupational chronic lead poisoning and 20 controls were examined.
RESULTSCompared with control group, CD3+ CD4+ lymphocytes and CD4/CD8 ratios decreased in patients with occupational chronic lead poisoning. The plasma IL-2 level were significantly raised while the IL-10 and IFN-gamma were reduced in patients with occupational chronic lead poisoning.
CONCLUSIONST lymphocyte subsets and plasma Th1/Th2 cytokine levels could be a new parameter to assess lead immunotoxicity.
