Association between non-syndromic cleft lip with or without cleft palate and environmental factors in Ningxia.
- Author:
Lili YU
1
;
Jian MA
2
;
Junpeng GAO
3
Author Information
- Publication Type:Journal Article
- Keywords: Logistic regression analysis; environmental factor; non-syndromic cleft lip with or without cleft palate
- MeSH: Case-Control Studies; China; epidemiology; Cleft Lip; epidemiology; Cleft Palate; epidemiology; Diet; Female; Humans; Incidence; Infant, Newborn; Parents; Pregnancy; Smoking
- From: West China Journal of Stomatology 2017;35(3):291-295
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between non-syndromic cleft lip with or without cleft palate (NSCL/P) and environmental factors in Ningxia population.
METHODSThis case-control study involved 453 NSCL/P patients and 452 normal newborns from Ningxia. A questionnaire focusing on various factors, including family history, pregnancy reaction, drug use during pregnancy, and infections, was used and responses were analyzed through Chi-square test and Logistic regression analysis with SPSS 16.0.
RESULTSThe constituent ratio of different types of NSCL/P was cleft lip∶cleft lip and palate∶cleft palate equal to 1︰2.02︰1.51. Logistic regression analysis revealed that abnormal pregnancy, infection, abortion, drugs, drinking, smoking, and living near factories likely increased the risk of NSCL/P (P<0.05). Single fetus, pregnancy-related nausea, vomiting, parents' moderate tastes, and eating soy foods and fruits decreased the risk of NSCL/P (P<0.05).
CONCLUSIONSThe incidence of NSCL/P should be reduced to enhance the conditions of women during pregnancy by maintaining a balanced diet and avoiding infections, abortion, drugs, and negative habits. .
