Clinical significance of CD44 and CD133 expression in oral potentially malignant disorder and oral squamous cell carcinoma.
- Author:
Jiajia QI
1
;
Yan SUN
1
;
Changqing YUAN
2
Author Information
- Publication Type:Journal Article
- Keywords: CD133; CD44; clinical significance; oral potentially malignant disorder; oral squamous cell carcinoma
- MeSH: AC133 Antigen; Carcinogenesis; Carcinoma, Squamous Cell; Humans; Hyaluronan Receptors; Lymphatic Metastasis; Mouth Mucosa; Mouth Neoplasms
- From: West China Journal of Stomatology 2017;35(3):311-316
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study aims to investigate the expression and relationship of CD44 and CD133 in normal oral mucosa, oral potentially malignant disorder (OPMD), and oral squamous cell carcinoma (OSCC). This work also analyzes the relationship between such expression and clinical factors. This study intends to evaluate the clinical value of using CD44 and CD133 as indices to evaluate the carcinogenic potential of OPMD.
METHODSClinical data from 60 patients with OPMD, 60 patients with OSCC, and 10 cases of normal oral mucosa were analyzed. Double immunohistochemical analysis was applied to investigate the expression of CD44 and CD133 in paraffin sections of normal oral mucosa, OPMD, and OSCC tissues. Subsequently, the relationships between such expression and clinical factors were analyzed.
RESULTSThe positive rates of CD44 expression in the normal oral mucosa, OPMD, and OSCC tissues were 100.00%, 96.67%, and 71.67% (P<0.05), respectively. Meanwhile, the positive rates of CD133 expression in the normal oral mucosa, OPMD, and OSCC tissues were 0.00%, 35.00%, and 63.33% (P<0.05), respectively. The expression of CD44 and CD133 was found to be correlated (P<0.05). Such expression was related to the clinical stages and lymphatic metastasis of OSCC (P<0.05).
CONCLUSIONSCD44 and CD133 can be used individually as clinical indices to evaluate the carcinogenic potential of OPMD. .
