Progress on matrix metalloproteinase inhibitors.
- Author:
Lingling JIA
1
;
Qianbing WAN
2
Author Information
- Publication Type:Journal Article
- Keywords: biodegradation; cysteine cathepsins; dentin; durability; enzyme inhibitors; matrix metalloproteinase
- MeSH: Acid Etching, Dental; Bisphenol A-Glycidyl Methacrylate; Collagen; Dental Bonding; Dentin; Dentin-Bonding Agents; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors
- From: West China Journal of Stomatology 2017;35(2):208-214
- CountryChina
- Language:Chinese
- Abstract: Continuing advances in dentin bonding technology and adhesives revolutionized bonding of resin-based composite restorations. However, hybrid layers created by contemporary dentin adhesives present imperfect durability, and degradation of collagen matrix by endogenous enzymes is a significant factor causing destruction of hybrid layers. Bond durability can be improved by using enzyme inhibitors to prevent collagen degradation and to preserve integrity of collagen matrix. This review summarizes progress on matrix metalloproteinase inhibitors (including chlorhexidine, ethylenediaminetetraacetic acid, quaternary ammonium salt, tetracycline and its derivatives, hydroxamic acid inhibitors, bisphosphonate derivative, and cross-linking agents) and suggests prospects for these compounds.
