Research progress on the relationship between triggering receptor expressed on myeloid cells 1 and 2 and malignant tumors.
- VernacularTitle:髓样细胞触发受体1和2与恶性肿瘤关系的研究进展
- Author:
Yun YANG
1
;
Wuchao WU
2
Author Information
- Publication Type:Journal Article
- Keywords: chronic inflammation; malignant tumour; triggering receptor expressed on myeloid cells 1; triggering receptor expressed on myeloid cells 2
- From: West China Journal of Stomatology 2017;35(6):648-653
- CountryChina
- Language:Chinese
- Abstract: Increasing scientific evidence supports the positive relationship between inflammation and cancer development. The immune response initiated by pattern recognition receptors is critical to triggering of tumor-associated inflammation. Triggering receptor expressed on myeloid cells (TREM) is an immunoglobulin of the super transmembrane glycoprotein family, which is mainly expressed on select groups of myeloid cells. The most important members of TREM comprise TREM-1 and TREM-2. Activation of TREM-1 and TREM-2 signaling is initiated upon binding of their ligands. Subsequently, cross-linking reactions of downstream effectors occur, resulting in inflammation regulation. Recently, the connection between TREM and malignant tumors has been widely noticed and studied. This review summarizes studies of association between TREM-1, TREM-2, and malignant tumors in the medical field to provide new ideas for study on the correlation between periodontitis and oral cavity cancer.
