Research advances on the molecular mechanism of autophagy regulated by Porphyromonas gingivalis.

Author: Yan ZHAO ¹ ; Yang YU ² ; Yurong KOU ³
Author Information

1. Dept. of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, China.
2. Dept. of Oral Biology, School of Stomatology, China Medical University, Shenyang 110002, China.
3. Dept. of Periodontics, School of
Publication Type:Journal Article
Keywords: Porphyromonas gingivalis; autophagy; gingival epithelial cell; vascular endothelial cell
From: West China Journal of Stomatology 2017;35(6):654-658
CountryChina
Language:Chinese
Abstract: Autophagy is an intracellular conservative degradation pathway. This event has been considered as a key step in host defense against bacterial infection. However, Porphyromonas gingivalis, as one of the evidence-sufficient periodontal pathogens, can utilize self-induced autophagy to achieve persistent intracellular survival and proliferation, which enable this organism to escape from host immune surveillance. This review focuses on molecular mechanism of P. gingivalis internalization and autophagy to illuminate its pathogenesis and to further explore the relationship between P. gingivalis and systemic diseases.