Correlation of Epstein-Barr virus infection and childhood lymphoma.
- Author:
Zheng-De XIE
1
;
Lin WANG
;
Di LU
;
Chun-Ju ZHOU
;
Kun-Ling SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Epstein-Barr Virus Infections; complications; metabolism; Female; Herpesvirus 4, Human; isolation & purification; Hodgkin Disease; complications; metabolism; virology; Humans; Lymphoma, Non-Hodgkin; complications; metabolism; virology; Male; Pseudolymphoma; complications; metabolism; virology; RNA, Viral; metabolism; Viral Matrix Proteins; metabolism
- From: Chinese Journal of Oncology 2008;30(5):365-367
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation of Epstein-Barr virus (EBV) infection and childhood lymphoma.
METHODSParaffin-embedded specimens of lymphoma collected between 1996 and 2005, including 36 Hodgkin lymphomas (HL) and 51 non-Hodgkin lymphomas (NHL), were included in this study. Paraffin-embedded specimens of reactive hyperplasia of lymph nodes (RL) collected during the same period were used as controls. Immunohistochemical (IHC) assay was used to detect EBV-LMP1 and in situ hybridization (ISH) to detect EBV-EBERs.
RESULTSEBV was detected in 72.2% (26/36) of the Hodgkin lymphomas, 15.7% (8/51) of the non-Hodgkin lymphomas and 33.3% (15/45) of the reactive hyperplasia of lymph nodes. There was a significant difference among Hodgkin lymphoma, non-Hodgkin lymphoma and RL (P = 0. 000).
CONCLUSIONChildhood Hodgkin lymphoma is closely correlated with Epstein-Barr virus infection. However, the low rate of EBV infection detected in childhood non-Hodgkin lymphoma might be due to heterogeneous distribution of pathological types in this study.
