Preliminary study of biweekly regimen of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin for advanced gastric cancer.
- Author:
Zhe-Hai WANG
1
;
Jun GUO
;
Zhen CHEN
;
Chang-Zheng LI
;
Li-Jun SHENG
;
Deng-Guang ZHOU
;
Bo LIU
;
Jie LIU
;
Qing-Cai WANG
;
En-Ning ZHANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adenocarcinoma; drug therapy; pathology; Adenocarcinoma, Mucinous; drug therapy; pathology; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Female; Fluorouracil; administration & dosage; adverse effects; Follow-Up Studies; Humans; Leucovorin; administration & dosage; adverse effects; Leukopenia; chemically induced; Liver Neoplasms; drug therapy; secondary; Lung Neoplasms; drug therapy; secondary; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Organoplatinum Compounds; administration & dosage; adverse effects; Remission Induction; Stomach Neoplasms; drug therapy; pathology; Taxoids; administration & dosage; adverse effects; Vomiting; chemically induced; Young Adult
- From: Chinese Journal of Oncology 2008;30(5):389-391
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and toxicity of a biweekly DOF regimen consisting of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin for advanced gastric cancer.
METHODSThe biweekly DOF regimen was administered in 37 advanced gastric cancer patients. Docetaxel, oxaliplatin and leucovorin were given intravenously at a dose of 35 mg/m2, 85 mg/m2 and 200 mg/m2 for 1 h, 2 h and 2 h on D1, respectively, and 5-Fu was administered as continuous intravenous infusion for 48 h at a dose of 1500 mg/m2 on D1 and D2. This regimen was repeated every 2 weeks. The efficacy and toxicity were evaluated after completion of 3 cycles at least.
RESULTSThe overall response rate (RR) of this series was 67.6%, complete response rate and partial response rate were 27.0% and 40.5%, respectively. The time to progression (TTP) was 9.2 months, and median survival time (MST) was 13.7 months. The RRs of 11 chemotherpy-naïve patients and 26 patients pre-treated with chemotherapy were 81.8% and 61.5%, respectively.
CONCLUSIONOur preliminary results showed that this biweekly combination regimen of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin is effective and tolerable for advanced gastric cancer. However, further investigation of this regimen is mandatory.
