High expression of proteasome subunit PSMA7 in colorectal cancer is significantly correlated with liver metastasis.
- Author:
Xiao-Tong HU
1
;
Wei CHEN
;
Da WANG
;
Qing-Lan SHI
;
Fu-Biao ZHANG
;
Yong-Qiang LIAO
;
Mei JIN
;
Chao HE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Colonic Neoplasms; enzymology; pathology; surgery; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; enzymology; secondary; Lymphatic Metastasis; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Proteasome Endopeptidase Complex; metabolism; Rectal Neoplasms; enzymology; pathology; surgery; Survival Rate; Young Adult
- From: Chinese Journal of Oncology 2008;30(7):515-518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between the proteasome subunit PSMA7 expression in colorectal cancer and its role in liver metastasis.
METHODSTo identify the PSMA7 protein expression in 62 primary site colorectal cancers, 34 lymph node metastatic sites and 13 liver metastatic sites by immunohistochemistry and clarify the correlation of its expression with the clinicopathological parameters.
RESULTSHigh expression of PSMA7 was detected in 38.7% (24/62) of primary site colorectal cancer, 52.9% (18/34) of lymph node metastatic sites and 100% (13/13) liver metastatic sites but not in the normal colorectal tissue. High expression of PSMA7 was significantly correlated with liver metastasis (P = 0.028). The survival rate was significantly lower in patients with high expression of PSMA7 than in those with low expression of PSMA7 (P = 0.0008). As well, in multivariate analysis, PSMA7 expression demonstrated to be an independent prognostic factor (P = 0.004, relative risk 5.057; 95% confidence interval, 1.682-15.201).
CONCLUSIONPSMA7 may play an important role in the colorectal cancer progression. Evaluation of PSMA7 expression in primary colorectal cancer at the time of surgery might be a valuable test in defining patients with a high risk of developing liver metastasis.
