Expression of TFPI-2 gene in pancreatic carcinoma and its prognostic significance.
- Author:
Zhi-gang TANG
1
;
Zhen-yang SUN
;
He-jie HU
;
Ge-liang XU
;
Jiong CHEN
;
Jian-sheng LI
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; surgery; Adult; Aged; Biomarkers, Tumor; Carcinoma, Papillary; metabolism; pathology; surgery; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glycoproteins; genetics; metabolism; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pancreatic Neoplasms; metabolism; pathology; surgery; Prognosis; Proportional Hazards Models; RNA, Messenger; metabolism; Survival Rate
- From: Chinese Journal of Oncology 2008;30(8):598-601
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of TFPI-2 gene in pancreatic carcinoma, and to evaluate its prognostic significance in patients with pancreatic carcinoma.
METHODSReverse transcription polymerase chain reaction (RT-PCR) and Western blot were used to detect the expression of TFPI-2 mRNA and protein in the pancreatic carcinoma tissue samples from 41 patients. The correlation of its expression with clinicopathological features and its prognostic significance were analyzed.
RESULTSThe expression of TFPI-2 mRNA and protein in moderately or poorly differentiated pancreatic carcinoma tissues, or in cases with nerve-involvement, lymph node and blood vessel invasion was significantly lower than that in the highly differentiated one, or without nerve involvement, or neither lymphatic nor blood vessel invasion (P < 0.05). The median survival time of patients with high expression of TFPI-2 (12.0 months) was significantly longer than that with low expression of TFPI-2 (5.1 months, P < 0.05). The Cox model analysis showed that the expression of TFPI-2 was an independent marker for prognosis in patients with pancreatic carcinoma.
CONCLUSIONThe expression of TFPI-2 is correlated with clinical stage and differentiation of pancreatic carcinoma, and can be used as a prognostic marker for pancreatic carcinoma.
