Correlation of IKZF1 Gene with Malignant Tumors and Systemic Lupus Erythematosus.
10.7534/j.issn.1009-2137.2015.02.058
- Author:
Qi WEN
1
;
Mei-Rong WU
1
;
Ying-Zhi HE
2
;
Yu-Hua LI
3
Author Information
1. Second Clinical Medical College of Southern Medical University, Guangzhou 510282, Guangdong Province, China.
2. Department of Hematology, Southern Medical University Zhujiang Hospital, Guangzhou 510282, Guangdong Province, China.
3. Department of Hematology, Southern Medical University Zhujiang Hospital, Guangzhou 510282, Guangdong Province, China. E-mail: li_yuhua@yahoo.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Ikaros Transcription Factor;
Lupus Erythematosus, Systemic;
Neoplasms;
Prognosis
- From:
Journal of Experimental Hematology
2015;23(2):591-595
- CountryChina
- Language:Chinese
-
Abstract:
IKZF1 gene located in 7p12 of chromosome, and Ikaros family zinc finger encoded by IKZF1, are lymphoid-restricted transcription factors. In recent years, it has been demonstrated that the mutation of IKZF1 gene involved in proliferation, metastasis and prognosis of many malignant tumor except acute lymphoblastic leukemia, and also involved in complex phenotypes and susceptibility to systemic lupus erythematosus. This review briefly introduces the molecular structure and physiological function of Ikaros, focusing on its function and molecular mechanism in proliferation, metastasis and prognosis of malignant tumors, and its role in the systemic lupus erythematosus.
