Relationship between RAD51-G135C and XRCC3-C241T Single Nucleotide Polymorphisms and Onset of Acute Myeloid Leukemia.

Lei MIAO; Xi-Feng QIAN; Guo-Hua YANG; Li-Dong ZHAO

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Relationship between RAD51-G135C and XRCC3-C241T Single Nucleotide Polymorphisms and Onset of Acute Myeloid Leukemia.

Author: Lei MIAO ¹ ; Xi-Feng QIAN ² ; Guo-Hua YANG ² ; Li-Dong ZHAO ³
Author Information

1. Department of Hematology, Lianyungang Hospital Affiliated to Xuzhou Medical College, Lianyungang 222000, Jiangsu Province, China.
2. Department of Hematology, Wuxi People's Hospital, Wuxi 214000, Jiangsu Province, China.
3. Department of Hematology, Lianyungang Hospital Affiliated to Xuzhou Medical College, Lianyungang 222000, Jiangsu Province, China. E-mail: zld060201@sina.com.
Publication Type:Journal Article
MeSH: DNA-Binding Proteins; Heterozygote; Homozygote; Humans; Leukemia, Myeloid, Acute; Polymorphism, Single Nucleotide; Rad51 Recombinase
From: Journal of Experimental Hematology 2015;23(3):605-611
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the relationship between RAD51-G135C and XRCC3-C241T single nucleotide polymorphisms and onset of acute myeloid leukemia (AML).
METHODSThe study was performed in 2 groups: AML patient group and normal person group as control group. Genomic DNA was extracted from peripheral blood cells of 545 AML patients and 1 034 normal persons. Genotypes of RAD51-G135C and XRCC3-C241T were analyzed by TaqMan probe technology and the ralatienship between RAD51-G135C/XRCC3-C241T polymorphisms and onset of acute myeloid leukemia was investigated.
RESULTSCompared with the control group, RAD51-G135C homozygous mutant (CC) could significantly increase the risk of AML patients (OR=3.07), and there was no statistical relationship between heterozygous mutant (GC) of RAD51-G135C and onset of AML. There was no statistical relationship between homozygous mutant (TT) of XRCC3-C241T and onset of AML, and the XRCC3-C241T heterozygous mutation type (CT) increased the risk of AML patients (OR=0.66).
CONCLUSIONRAD51-G135C homozygous mutant and XRCC3-C241T heterozygous mutation significantly increase the risk of the AML onset, which can provide more predictive value for incidence of AML.