Analysis of the Detection for the LPD Patients with EB Infection.

Jin SU; Shu-yi Wang; Peng Liu

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Analysis of the Detection for the LPD Patients with EB Infection.

Author: Jin SU ¹ ; Shu-Yi WANG ² ; Peng LIU ³
Author Information

1. Department of Clinical Laboratorial Examination, The Traditional Chinese Medicine Hospital of Funing County, Funing 066300, Hebei Province, China. E-mail: wsujin@126.com.
2. Department of Clinical Laboratorial Examination, The First Hospital of Qinhuangdao City, Qinhuangdao 066000, Hebi Province, China.
3. Department of Clinical Laboratorial Examination, The Third Hospital of Qinhuangdao City, Qinhuangdao 066000, Hebi Province, China.
Publication Type:Journal Article
MeSH: Cytokines; DNA, Complementary; DNA, Viral; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Leukocytes, Mononuclear; Lymphoproliferative Disorders
From: Journal of Experimental Hematology 2015;23(3):702-705
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo analyze the detection results for the patients with lymphoproliferative disease(LPD) accompanied with the infection of EB.
METHODSThe EBV specific antibody, serum cytokine, EBV DNA copy number in peripheral blood mononuclear cells (PBMNC) of 70 LPD patients and 70 healthy volunteers were analyzed and compared.
RESULTSThe positive rates of VCA-IgG and VCA-IgM were not significantly different in two groups (P>0.05); The positive rate of EA-IgG in the PLD patient group was higher than that in the control group (P<0.05); the levels of IL-18 and IFN-γ were not significantly different between the 2 group (P>0.05); the EBV DNA copy number in PBMNC of the PLD patient group was higher than that in the control group (P<0.05).
CONCLUSIONThe patients with LPD show the active infection of EBV, that is the main reason for the abnormal function of lymphatic system in the patients with LPD. The active infection of EBV maybe involve in PLD pathogenesis.