Assessment value of preoperative neutrophil-lymphocyte ratio for the prognosis of patients with colorectal cancer after radical operation.
- Author:
Hai-liang LIU
1
;
Xiao-hui DU
;
Pei-ming SUN
;
Chun-hong XIAO
;
Zhen-yu ZOU
;
Ying-xin XU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Colorectal Neoplasms; blood; diagnosis; pathology; Female; Humans; Lymphatic Metastasis; Lymphocytes; pathology; Male; Neutrophils; pathology; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Rate
- From: Chinese Journal of Gastrointestinal Surgery 2013;16(8):723-726
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the value of preoperative neutrophil-lymphocyte ratio (NLR) for prognosis in patients with colorectal cancer after radical operation.
METHODSClinical data of 140 patients with colorectal cancer undergoing radical operation in the Department of General Surgery of General Hospital of PLA from July 2005 to July 2011 were analyzed retrospectively. According to preoperative NLR, patients were divided into the low NLR group (NLR<5, n=105) and the high NLR group (NLR≥5, n=35). The overall 5-year survival rates of two groups were compared and the independent risk factors were examined by univariate analysis and Cox model.
RESULTSThe overall 5-year survival rates of the low and high NLR groups were 74.8% and 54.7% respectively with significant difference (P=0.03). Univariate analysis revealed depth of tumor, lymph nodes metastasis, TMN stage and NLR were associated with survival (P<0.05, P<0.01). Cox model showed that NLR was independent risk factor of prognosis (RR=1.068, 95%CI:1.009-1.129, P=0.02).
CONCLUSIONPreoperative NLR≥5 predicts poorer prognosis of colorectal cancer patients.
