Effects of different dosages of cyclosporine A on the semen parameters of renal transplant patients.
- Author:
Long-Gen XU
1
;
Hui-Ming XU
;
Jun-Rong ZHANG
;
Qi-Zhe SONG
;
Xiao-Ping QI
;
Xin-Hong WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Cyclosporine; pharmacology; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; pharmacology; Kidney Transplantation; Male; Semen; drug effects; Sperm Count; Sperm Motility; drug effects; Spermatozoa; drug effects
- From: National Journal of Andrology 2003;9(9):679-683
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo evaluate the effects of different dosages of cyclosporine A (CsA) on the main semen parameters and sperm morphology of the patients after renal transplantation.
METHODSThe semen of 18 patients after renal transplantation treated with different dosages of CsA was analyzed and the semen parameters and sperm morphology were compared with those of 12 normal volunteers.
RESULTSThere was not significant difference between the main parameters of the patients treated with 1.5-3.0 mg.Kg-1.d-1 of CsA and 3.1-5.5 mg.Kg-1.d-1 of CsA and those of the volunteers (P > 0.05), but the rate of normal sperm morphology was significantly different between the two groups(P < 0.05).
CONCLUSIONSDifferent therapeutic dosages of CsA did not have any effect on most of the semen parameters of the patients after renal transplantation, but did affect the sperm morphology.
