Expression of CD44v6 and E-cadherin in prostate carcinoma and metastasis of prostate carcinoma.
- Author:
Huaping GU
1
;
Peizhong SHANG
;
Cuiling ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Cadherins; analysis; Cell Differentiation; Glycoproteins; analysis; Humans; Hyaluronan Receptors; analysis; Immunohistochemistry; Male; Neoplasm Metastasis; Prostatic Neoplasms; chemistry; pathology
- From: National Journal of Andrology 2004;10(1):32-38
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of CD44v6 and E-cadherin(ED) in prostate carcinoma in relation to the metastasis of prostate carcinoma.
METHODSThe expression of CD44v6 and ED in 45 cases of prostate carcinoma was studied with immunohistochemical technique.
RESULTSThe positive expression rates of CD44v6 and ED in prostate carcinoma were 77.8% and 48.9%, respectively. The high level expression of CD44v6 and the low level expression of ED were positively correlated with differentiation, clinical staging and metastasis of prostate carcinoma (P < 0.05). The expression of CD44v6 was negatively correlated with ED(r = -0.58, P < 0.005).
CONCLUSIONSThe expression of CD44v6 and ED protein might be a useful marker for prostate carcinoma in evaluating the biological behavior and prognosis of the tumor.
