Experimental research of PDE5 activity in corpora cavernosa of ganyu qizhi rat model.
- Author:
Degui CHANG
1
;
Zhengyi WANG
;
Bide ZHU
;
Jiuyuan WANG
;
Shuwu ZHANG
;
Zhiping HU
Author Information
- Publication Type:Journal Article
- MeSH: 3',5'-Cyclic-GMP Phosphodiesterases; metabolism; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Drugs, Chinese Herbal; pharmacology; Erectile Dysfunction; etiology; Male; Medicine, Chinese Traditional; Models, Animal; Penis; drug effects; enzymology; Rats; Rats, Sprague-Dawley
- From: National Journal of Andrology 2004;10(1):71-73
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo study the PDE5 activity in corpora cavernosa of the Ganyu Qizhi model penis and the effect of the Chinese herbal medicine Shugan Liqi Huoxue (SLH) ointment on it.
METHODSNon-injury stress stimulus method similar to human spirit stress was used to extablish the Ganyu Qizhi animal(rat) model, and the PDE5 activity in corpora cavernosa of the rat penis was measured by the method of immunohistochemistry and computer image analysis.
RESULTSThe PDE5 activity in corpora cavernosa of the high-dosage SLH group was significantly different from that of the model group (P < 0.01).
CONCLUSIONGanyu Qizhi may increase the PDE5 activity in corpora cavernosa of the penis while SLH can reduce such activity.
