Expression and significance of activated leukocyte cell adhesion molecule in prostatic intraepithelial neoplasia and adenocarcinoma.
- Author:
Xiangyi ZHENG
1
;
Wei DING
;
Liping XIE
;
Zhaodian CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Activated-Leukocyte Cell Adhesion Molecule; analysis; Adenocarcinoma; chemistry; pathology; Aged; Aged, 80 and over; Humans; Immunohistochemistry; Male; Middle Aged; Prostatic Intraepithelial Neoplasia; chemistry; pathology; Prostatic Neoplasms; chemistry; pathology
- From: National Journal of Andrology 2004;10(4):265-268
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of activated leukocyte cell adhesion molecule(ALCAM) protein in prostatic intraepithelial neoplasia and adenocarcinoma, and the relationship between ALCAM expression and clinicopathological features of prostatic carcinoma.
METHODSALCAM protein expression was evaluated in the tissues of 41 human prostatic carcinomas by using immunohistochemistry (EnVision method).
RESULTSALCAM was widely expressed in prostatic epithelia. Overexpression of ALCAM was found in most prostatic intraepithelial neoplasias and low-grade cancers, whereas a decreased expression shown in some high-grade cancers. The ALCAM protein expression in prostatic carcinoma was correlated with pathological grading. However, no correlation of ALCAM expression was found with preoperative serum prostate-specific antigen levels or clinical stages.
CONCLUSIONExpression of ALCAM is disturbed in prostatic intraepithelial neoplasia and adenocarcinoma, indicating its involvement in the development of human prostatic carcinoma.
