The investigation of bioadhesive property of carbomer 934 by gamma camera in vivo.
- Author:
Jie FU
1
;
Xun SUN
;
Zhirong ZHANG
Author Information
1. West China School of Pharmacy, Sichuan University, Chengdu 610041.
- Publication Type:Journal Article
- MeSH:
Acrylic Resins;
pharmacokinetics;
Animals;
Cellulose;
analogs & derivatives;
pharmacokinetics;
Digestive System;
diagnostic imaging;
Dogs;
Gamma Cameras;
Gastric Emptying;
Intestinal Mucosa;
metabolism;
Radioimmunodetection
- From:
Journal of Biomedical Engineering
2002;19(3):423-425
- CountryChina
- Language:Chinese
-
Abstract:
To study bioadhesive property of carbomer 934 in dog alimentary tract, carbomer 934 and ethylcellulose were radiolabelled with technetium-99 m. The gastrointestinal emptying rate of these materials was measured by the technique of gamma scintiscan. The results showed that the empty rate of adhesive material (carbomer 934) was remarkably slower in dog alimentary tract compared to nonadhesive material (ethylcellulose). It is concluded that, in dog, the interaction between gastrointestinal mucus layer and adhesive material or nonadhesive material was significantly different. Carbomer 934 had stronger bioadhesive property in vivo than that of ethylcellulose.
