GM6001 suppresses scar formation after glaucoma filtration surgery in rabbits.
- Author:
Ying SHEN
1
;
Wei WU
;
Xiaohe LU
;
Wenqi GUO
Author Information
- Publication Type:Journal Article
- MeSH: Actins; metabolism; Animals; Cicatrix; pathology; prevention & control; Dipeptides; pharmacology; Filtering Surgery; adverse effects; Glaucoma; surgery; Intraocular Pressure; Postoperative Complications; Proliferating Cell Nuclear Antigen; metabolism; Rabbits
- From: Journal of Southern Medical University 2014;34(2):241-245
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of matrix metalloproteinases inhibitor GM6001 in suppressing scar tissue formation in the filtering passage after glaucoma filtration surgery.
METHODSTwenty-four pigmented rabbits (48 eyes) underwent trabeculectomy followed by subconjunctival injection of GM6001 in the right eye (treated eyes) and injection of PBS in the left eye (control) once a day. The intraocular pressure was monitored postoperatively and proliferating cell nuclear antigen (PCNA)- and α-smooth muscle actin (α-SMA)-positive cells in the filtering pathway were detected using immunohistochemistry.
RESULTSOn postoperative days 7, 14, 21, and 28, the intraocular pressure was significantly lower in the treated eyes (GM6001) than in the control eyes (P<0.01). The counts of PCNA- and α-SMA-positive cells were also significantly lowered in the treated than in the control eyes (P<0.01).
CONCLUSIONGM6001 can inhibit excessive proliferation of the fibroblasts in the filtering pathway to suppress scar tissue formation and prolong the existence of the functional filtration bleb in rabbits.
