Detection of serum food specific antibodies of 6 common foods in patients with IgA nephropathy.
- Author:
Chaomin ZHOU
1
;
Zhigang LIU
;
Weiguo SUI
;
Dongfeng GU
;
Yongqiang LI
;
Hequn ZOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antibody Specificity; Case-Control Studies; Female; Food Hypersensitivity; classification; immunology; Glomerulonephritis, IGA; blood; immunology; Humans; Immunoglobulin A; blood; Immunoglobulin E; blood; Immunoglobulin G; blood; Male; Young Adult
- From: Journal of Southern Medical University 2014;34(3):419-422
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between the major allergens of 6 common allergic foods and IgA nephropathy.
METHODSA sensitive sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of food-specific IgA1, IgG and IgE in 31 patients with IgA nephropathy and 80 healthy volunteers. All the patients were examined for a history of food allergy using a questionnaire.
RESULTSSerum levels of IgA1 and IgG against the major allergens of the 6 common allergic foods were significantly higher in patients with IgA nephropathy than in healthy volunteers (P<0.05). There was no detectable food-specific IgE antibodies in the two groups. No patients had a clear history of food allergy. All the patients with increased IgG levels specific to 4 or more foods simultaneously had proteinuria.
CONCLUSIONSSome foods especially the highly allergic ones may participate in the pathogenesis and progression of IgA nephropathy.
