Patterns of Lymph Node Recurrence after Radical Surgery Impacting on Survival of Patients with pT1-3N0M0 Thoracic Esophageal Squamous Cell Carcinoma.
10.3346/jkms.2014.29.2.217
- Author:
Xiao Li CHEN
1
;
Tian Wu CHEN
;
Zhi Jia FANG
;
Xiao Ming ZHANG
;
Zhen Lin LI
;
Hang LI
;
Hong Jie TANG
;
Li ZHOU
;
Dan WANG
;
Zishu ZHANG
Author Information
1. Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China. tianwuchen_nsmc@163.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Esophageal Squamous Cell Carcinoma;
Thorax;
Lymph Node Recurrence;
Tomography, X-Ray Computed;
Radical Esophagectomy
- MeSH:
Aged;
Aged, 80 and over;
Carcinoma, Squamous Cell/mortality/pathology/*surgery;
Esophageal Neoplasms/mortality/pathology/*surgery;
Female;
Follow-Up Studies;
Humans;
Lymph Nodes/*pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Recurrence, Local;
Neoplasm Staging;
Odds Ratio;
Postoperative Period;
Proportional Hazards Models;
Survival Analysis;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2014;29(2):217-223
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to investigate how patterns of lymph nodes recurrence after radical surgery impact on survival of patients with pT1-3N0M0 thoracic esophageal squamous cell carcinoma. One hundred eighty consecutive patients with thoracic esophageal squamous cell carcinoma underwent radical surgery, and the tumors were staged as pT1-3N0M0 by postoperative pathology. Lymph nodes recurrence was detected with computed tomography 3-120 months after the treatment. The patterns of lymph nodes recurrence including stations, fields and locations of recurrent lymph nodes, and impacts on patterns of survival were statistically analyzed. There was a decreasing trend of overall survival with increasing stations or fields of postoperative lymph nodes involved (all P<0.05). Univariate analysis showed that stations or fields of lymph nodes recurrence, and abdominal or cervical lymph nodes involved were prognostic factors for survival (all P<0.05). Cox analyses revealed that the field was an independent factor (P<0.05, odds ratio=2.73). Lymph nodes involved occurred predominantly in cervix and upper mediastinum (P<0.05). In conclusion, patterns of lymph node recurrence especially the fields of lymph nodes involved are significant prognostic factors for survival of patients with pT1-3N0M0 thoracic esophageal squamous cell carcinoma.
