Effect of three different curcumin pigmens on the prdiferation of vascular smooth muscle cells by ox-LDL and the expression of LDL-R.
- Author:
Yan LIU
1
;
Xing-Qiu HONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aorta; cytology; Cattle; Cell Proliferation; drug effects; Cells, Cultured; Curcuma; chemistry; Curcumin; analogs & derivatives; isolation & purification; pharmacology; Lipoproteins, LDL; antagonists & inhibitors; Muscle, Smooth, Vascular; cytology; Myocytes, Smooth Muscle; cytology; metabolism; Plants, Medicinal; chemistry; Receptors, LDL; metabolism; Structure-Activity Relationship
- From: China Journal of Chinese Materia Medica 2006;31(6):500-503
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the anti-proliferation of three different structural curcumin pigmen monomers on the bovine VSMC stimulated by ox-LDL and the effect on the expression of LDL-R.
METHODMTT and FCM were used to observe the anti-proliferation of three different on the bovine VSMC stimulated by ox-LDL and the effect on the expression of LDL-R.
RESULTox-LDL(2.5,5, 10 mg x L(-1)) had obvious proliferative effect on VSMC, P < 0.05, curcumin (16.5,33,66 micromol x L(-1)), demethoxycurcumin (33,66 micromol x L(-1)) and bisdemethoxycurcumin (66 micromol x L(-1)) had obvious inhibition effect on the proliferation of VSMC stimulated by 10 mg x L(-1) ox-LDL (P < 0.05, curcumin > demethoxycurcumin > bisdemethoxycurcumin) . Three curcumin (16.5,33,66 micromol x L(-1)) could obviously activate the expression of LDLR of VSMC.
CONCLUSIONThe three different structural curcumin pigmen monomers can not only inhibit the proliferation of bovine VSMC obviously stimulated by ox-LDL, but also promote the expression of LDL-R on bovine VSMC, that may be the mechanism of delaying the development of arteriosclerosis.
