Study of chemical constituents in stem rind of Daphne giraldii.
- Author:
Guang-Xiong ZHOU
1
;
Yong-Chun YANG
;
Jian-Gong SHI
Author Information
- Publication Type:Journal Article
- MeSH: Analgesics; chemistry; isolation & purification; pharmacology; Caffeic Acids; chemistry; isolation & purification; pharmacology; Daphne; chemistry; Diterpenes; chemistry; isolation & purification; pharmacology; Heterocyclic Compounds, 4 or More Rings; chemistry; isolation & purification; pharmacology; Molecular Structure; Plant Stems; chemistry; Plants, Medicinal; chemistry
- From: China Journal of Chinese Materia Medica 2006;31(7):555-557
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the constituents with the pain-relieving activity from the stem rind of Daphne giraldii.
METHODThe partition of the ethanol extract and chromatographic separation of the fractions were carried out by the monitoring of anelgesic pharmacological activity. The structures of the isolated compounds were determined by MS and NMR.
RESULTFour compounds were isolated from the pain-relieving fraction. Three of them were identified as diterpenes, gniditrin (1), gnidicin (2) and daphnetoxin (3). Compound 4 was determined as Z-octadecyl caffeate.
CONCLUSIONCompounds 1, 2 and 4 were isolated from the plant for the first time.
