Inhibitory effect of Panax notoginseng on the VSMC proliferation induced by hyperlipidemia serum.
- Author:
Jing WANG
1
;
Jin-Hong HU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aorta, Thoracic; cytology; Cell Proliferation; drug effects; Cells, Cultured; Drugs, Chinese Herbal; isolation & purification; pharmacology; Hyperlipidemias; blood; Male; Muscle, Smooth, Vascular; cytology; Myocytes, Smooth Muscle; cytology; Panax notoginseng; chemistry; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Serum
- From: China Journal of Chinese Materia Medica 2006;31(7):588-590
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of P. notoginseng on vascular smooth muscle cell (VSMC) proliferation induced by hyperlipidemia serum.
METHODMTT method was used to investigate the effect of hyperlipidemia serum and hyperlipidemia plus P. notoginseng on VSMC proliferation.
RESULTHyperlipidemia serum could promote VSMC proliferation significantly as compared with the control group (P < 0.05), while hyperlipidemia plus P. notoginseng could weaken this effect significantly (P < 0.05).
CONCLUSIONP. notoginseng can significantly inhibit the VSMC proliferation induced by hyperlipidemia serum.
