Experimental study of Bailian Caogen granule on pharmacodynamics.
- Author:
Run-ying ZHAO
1
;
Li-ni ZHAO
;
Yan-xiang ZHOU
;
Da-man LI
;
Wei HAO
;
Kui-min CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Acetic Acid; Analgesics, Non-Narcotic; pharmacology; Animals; Body Temperature; drug effects; Coptis; chemistry; Drug Combinations; Drugs, Chinese Herbal; pharmacology; Edema; pathology; prevention & control; Female; Fever; physiopathology; prevention & control; Glycyrrhiza uralensis; chemistry; Hot Temperature; Hyperalgesia; etiology; physiopathology; prevention & control; Male; Mice; Pain; chemically induced; physiopathology; prevention & control; Pain Threshold; drug effects; Phellodendron; chemistry; Plants, Medicinal; chemistry; Pueraria; chemistry; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2006;31(8):672-675
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the analgesic, antipyretic and anti-inflammatory effect of Bailian Caogen granule.
METHODThe antipyretic effects of Bailian Caogen granule was evaluated in rabbit fever model induced by peptone. The analgesic effect of the drug was studied with pain model of mice induced by acetic acid and hot plate, The severity of oedema in inflamed animal was observed to study the anti-inflammatory effects of Bailian Caogen granule.
RESULTBailian Caogen granule could obviously inhibit the fever of rabbits. The number of writhing induced by acetic acid was reduced and the pain threshold of mice was increased by Bailian Caogen granule. Bailian Caogen granule also had anti-inflammatory activity against xylene-induced mouse ear swelling and carrageenin-induced rat paw edema.
CONCLUSIONBailian Caogen granule has significant analgesic, antipyretic and anti-inflammatory activities.
