Effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane in anesthetized dogs and rats.
- Author:
Da-fang ZHANG
1
;
Xiu-hua WANG
;
Li-jing LI
;
Wen-jing CAI
;
Ya-jie ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Anesthesia; Animals; Brain; blood supply; Cerebrovascular Circulation; drug effects; Codonopsis; chemistry; Dogs; Drug Combinations; Drugs, Chinese Herbal; pharmacology; Female; Ligusticum; chemistry; Male; Microcirculation; drug effects; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Wistar; Tablets; Vascular Resistance; drug effects
- From: China Journal of Chinese Materia Medica 2006;31(8):680-683
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane.
METHODCerebral blood stream flux, resistance of blood vessels, blood pressure and heart rate were used as observation indexes in hemodynamics experiment. Artery caliber and the number of capillaries with recovered blood stream were used as observation indexes in microcirculation experiment.
RESULTNaoan tablets at dose of 0.5 g x kg(-1) and 1.0 g x kg(-1) could enhance cerebral blood stream flux, decrease resistance of blood vessels, and reduce blood pressure. While no effects on heart rate. Naoan tablet at dose of 0.7 g x kg(-1) and 2.1 g x kg(-1) could increase the number of capillaries with recovered blood stream and enlarge the artery caliber of soft membrane in rats.
CONCLUSIONNaoan tablets can improve the indexes of hemodynamics and cerebral microcirculation of soft membrane.
